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They had been carrying out X-ray diffraction analysis of DNA in the unit since Maybut Randall had not informed them that he had asked Franklin to take over both the DNA diffraction work and guidance of Gosling's thesis. She used a new fine-focus X-ray tube and microcamera ordered by Wilkins, but which she refined, adjusted and focused carefully.
Drawing upon her physical chemistry background, she also skillfully manipulated the critical hydration of her specimens. In her lecture notes, Franklin wrote the following : In stark contrast, Wilkins was very shy, and slowly calculating in speech while he avoided looking anyone directly in the eye.
The biological functions of A-DNA were only discovered 60 years later.
|Great by Design (14)||She used a new fine-focus X-ray tube and microcamera ordered by Wilkins, but which she refined, adjusted and focused carefully. Drawing upon her physical chemistry background, she also skillfully manipulated the critical hydration of her specimens.|
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Franklin chose the data rich "A" form while Wilkins selected the "B" form   because, according to his self-written biography, Wilkins' preliminary pictures had hinted it might be helical.
The X-ray diffraction pictures, including the landmark Photo 51taken by Franklin at this time have been called by John Desmond Bernal as "amongst the most beautiful X-ray photographs of any substance ever taken".
She must have mailed them while the Cambridge team was building their model, and certainly had written them before she knew of their work. He then published an evaluation of the draft's close correlation with the third of the original trio of 25 April Nature DNA articles.
Since Wilkins was not in his office, Watson went to Franklin's lab with his urgent message that they should all collaborate before Pauling discovered his error. The unimpressed Franklin became angry when Watson suggested she did not know how to interpret her own data.
Watson hastily retreated, backing into Wilkins who had been attracted by the commotion. Much of their data was derived directly from research done at King's by Wilkins and Franklin.
Franklin's research was completed by Februaryahead of her move to Birkbeck, and her data was critical.
She took the view that building a model was to be undertaken only after enough of the structure was known. Photographs of her Birkbeck work table show that she routinely used small molecular models, although certainly not ones on the grand scale successfully used at Cambridge for DNA.
In the middle of FebruaryCrick's thesis advisor, Max Perutzgave Crick a copy of a report written for a Medical Research Council biophysics committee visit to King's in Decembercontaining many of Franklin's crystallographic calculations. By 28 FebruaryWatson and Crick felt they had solved the problem enough for Crick to proclaim in the local pub that they had "found the secret of life".
Wilkins came to see the model the following week, according to Franklin's biographer Brenda Maddox on 12 March, and allegedly informed Gosling on his return to King's. Franklin did modify this draft later before publishing it as the third in the trio of 25 April Nature articles.
On 18 March,  in response to receiving a copy of their preliminary manuscript, Wilkins penned the following: As a result of a deal struck by the two laboratory directors, articles by Wilkins and Franklin, which included their X-ray diffraction data, were modified and then published second and third in the same issue of Nature, seemingly only in support of the Crick and Watson theoretical paper which proposed a model for the B form of DNA.
She is reported to have commented, "It's very pretty, but how are they going to prove it? As such, her response to the Watson-Crick model was in keeping with her cautious approach to science.
At first mainly geneticists embraced the model because of its obvious genetic implications. Her new laboratories were housed in 21 Torrington Square, one of a pair of dilapidated and cramped Georgian houses containing several different departments; Franklin frequently took Bernal to task over the careless attitudes of some of the other laboratory staff, notably after workers in the pharmacy department flooded her first-floor laboratory with water on one occasion.
Despite the ARC funding, Franklin wrote to Bernal that the existing facilities remained highly unsuited for conducting research " Her meeting with Aaron Klug in early led to a longstanding and successful collaboration.
They soon discovered published in that the covering of TMV was protein molecules arranged in helices. In he and Franklin published individual but complementary papers in the 10 March issue of Nature, in which they showed that the RNA in TMV is wound along the inner surface of the hollow virus.
The previous year, Franklin had visited the University of California, Berkeleywhere colleagues had suggested her group research the polio virus.
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